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ACADIA Pharmaceuticals Announces Positive Top-line Results from ADVANCE Trial of Pimavanserin as Treatment for Negative Symptoms of Schizophrenia [news release]. Citrome L, Zeni CM, Correll CU. Links will not be permitted. Accessed February 18, 2020. T.gondii parasites. The drugs work well against positive symptoms in about 70% of patients, said Dr. Donald Goff, a professor of psychiatry at New York University School of Medicine, in New York City. And because many of the traditional medications used to treat the disorder cause major side effects, those with schizophrenia can be reluctant to take them. Madrid, Spain: Laboratorios Farmacéuticos ROVI; March 19, 2019. edisongroup.com/publication/doria-phase-iii-trial-hits-primary-endpoint/23705. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. November 16, 2020 Source: University of Leeds Summary: New research into how a common parasite infection alters human behavior could help development of treatments for schizophrenia … Keeping up with the therapeutic advances in schizophrenia: a review of novel and emerging pharmacological entities. Cognitive effects of MIN-101 in patients with schizophrenia and negative symptoms: results from a randomized controlled trial. Accessed February 24, 2020. This review summarizes the schizophrenia treatment guidelines, current treatment strategies, and emerging agents for the management of schizophrenia. Though the team stress the sample size was too small to show if Methotrexate could work as an add-on treatment for schizophrenia, they found a ‘puzzling’ therapeutic effect on symptoms of early schizophrenia. Accessed February 18, 2020. Practice guideline for the treatment of patients with schizophrenia, second edition. The phase 2 trial was a randomized, double-blind, placebo-controlled, flexible-dose study that took place over 4 weeks in 245 hospitalized patients. News Nov 17, 2020 | Original story from the University of Leeds . Fellner C. New schizophrenia treatments address unmet clinical needs. WRITTEN BY: Annie Lennon Researchers from the UK and France have discussed a mechanism of action behind the infamous Toxoplasma gondii parasite transferred to humans from cat litter that may lead to the development of new treatments for schizophrenia and other neurological … But, Goff said, they do not ease the "negative" symptoms that plague people with schizophrenia. San Diego, CA: ACADIA Pharmaceuticals; November 25, 2019. ir.acadia-pharm.com/news-releases/news-release-details/acadia-pharmaceuticals-announces-positive-top-line-results?field_nir_news_date_value[min]=. Sunovion and PsychoGenics announce positive results from pivotal phase 2 study of novel investigational agent SEP-363856 for the treatment of schizophrenia. Schizophrenia. Overall, the effectiveness was maintained, Koblan said. A new drug designed to treat acute psychosis in schizophrenic patients is reporting impressively positive results from a Phase 2 clinical trial. Diagnosis of schizophrenia involves ruling out other mental health disorders and determining that symptoms are not due to substance abuse, medication or a medical condition. 136. All rights reserved. Hear details from the phase II trial of xanomeline-trospium and how it assists in the treatment of acute schizophrenia… Accessed November 20, 2019. FDA approved new antipsychotic drug for treatment of schizophrenia: Caplyta (lumateperone). WASHINGTON, D.C., Sept. 1, 2020 – The American Psychiatric Association (APA) today released a new evidence-based practice guideline to enhance the treatment of patients with schizophrenia. Schizophrenia is a chronic neuropsychiatric disorder that has a significant impact on the functioning and quality of life of individuals affected by the disease. Olanzapine also demonstrated similar improvements from baseline PANSS scores compared with placebo (P = .004). Medication is currently the main method of treating schizophrenia, and the primary type of medication is a class of drugs called antipsychotics. Marlborough, MA, and Paramus, NJ: Sunovion Pharmaceuticals Inc and PsychoGenics Inc; May 10, 2019. news.sunovion.com/press-release/sunovion-and-psychogenics-announce-sep-363856-has-received-fda-breakthrough-therapy. Furthermore, significant antipsychotic efficacy was observed as early as week 1 with lumateperone 60 mg and maintained throughout the entire study. Accessed November 24, 2019. Read Time: New research into how a common parasite infection alters human behavior could assist the creation of treatments for schizophrenia and other neurological disorders. The study had 2 primary end points: (1) percent change from baseline in body weight at 6 months, and (2) the proportion of participants with 10% or more weight gain from baseline at 6 months. 2,3 Adherence with (limited) treatment options for this patient population are suboptimal. Antipsychotics used to treat schizophrenia are not effective for all patients, do not target all symptoms of the disease, and have serious adverse side effects. Relatively newer, second-generation antipsychotics are less likely to cause those side effects, but they can spur weight gain and high blood sugar and cholesterol levels. Just 1% of patients in each arm reported serious AEs, and discontinuation was low at 2.5% for pimavanserin and 0% for placebo. Furthermore, 80% to 90% of individuals will experience a relapse at some point in the course of their illness, often related to nonadherence to maintenance therapy.23 Market research analysis has identified several gaps in pharmacologic therapy for schizophrenia, which include a need for agents that improve cognition, are capable of treating negative symptoms, improve treatment-resistant schizophrenia, have improved AE profiles, and improve adherence.23 Novel therapies that attempt to fill these treatment gaps have recently been approved or are currently being researched and will be discussed in more detail here. 0. clinicaltrials.gov/ct2/show/NCT02694328. All rights reserved. Symptoms of hallucinations and delusions mark this mental disorder, changing the lives of patients and their families. In particular, AEs such as the hypoesthesia and dysgeusia associated with sublingual asenapine could be avoided by utilizing the transdermal patch.26 A release date for this product has not yet been confirmed. Marlborough, MA, and Paramus, NJ: Sunovion Pharmaceuticals Inc and PsychoGenics Inc; December 13, 2018. news.sunovion.com/press-release/sunovion-and-psychogenics-announce-positive-results-pivotal-phase-2-study-novel. Espinoza S, Leo D, Sotnikova TD, Shahid M, Kääriäinen TM, Gainetdinov RR. American Journal of Psychiatry. Research into the treatment of schizophrenia is long overdue, as it can be a devastating disease process. Currently available antipsychotics, which are thought to work primarily via modulation of dopamine, largely target positive symptoms.4 As a result, many patients are left with residual negative and cognitive symptoms.4 To address these gaps in therapy, new research combined with an increased understanding of the etiology and pathophysiology of schizophrenia is leading to the development of novel agents with the goal of improving schizophrenia management. Approximately 30% of individuals with schizophrenia are considered resistant to currently available drug therapies. The APA recommends SGAs as first-line treatment of schizophrenia, excluding clozapine due to its AE profile.12 SGAs are preferred over FGAs because they are less often associated with extrapyramidal side effects (EPS), although SGAs are more often associated with metabolic AEs (eg, weight gain, hyperlipidemia, and diabetes mellitus).12 Combination therapy or treatment with clozapine is reserved for patients who have a partial or poor response to standard treatment with SGAs. O n December 23, the FDA approved a new drug for schizophrenia, lumateperone, which was said to be a “first-in-class” medication, suggesting that its mechanism of action differed from antipsychotic drugs … While those drugs are numerous, Goff said, they all work in a similar manner — by blocking a receptor on brain cells called D2, which interacts with the chemical dopamine. Lifelong treatment 25, 2019. edisongroup.com/publication/doria-phase-iii-trial-hits-primary-endpoint/23705 Barnes TR, Jones PB ( 50 mg/day or 75 mg/day ) or.. Clinically defined primary psychotic disorder, NY: Intra-Cellular Therapies, Inc ; www.intracellulartherapies.com/docs/caplyta_pi.pdf!, Dmitrienko a, Glass S, Sukhanov I, et al 65 % responding. Forgotten, or positive, symptoms of the National Alliance on Mental illness related.... Are considered resistant to currently available drug Therapies psychotic, or positive, symptoms of is... Trace amine-associated receptor 1 ( TAAR1 ) agonist RO5263397 in schizophrenia randomised controlled trial wrote an editorial published with therapeutic..., because this was a short-term trial positive effects against some prominent schizophrenia symptoms drugs schizophrenia. Were headache, somnolence, agitation, nausea, diarrhea, and Paramus, NJ: Sunovion Pharmaceuticals and. 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